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1 Surname_____________ Name____________Registration ID (matricola)_____________ Technologies for regenerative medicine - Prof. Manuela T. Raimondi 2019.June.25- test ------------------------------------------------------------------------------------------------------------------- RULES 1. The exam duration is 60 minutes. 2. The use of a calculator, or any other electronic device, is forbidden. 3. You may not copy and / or converse. 4. Answers will be evaluated only if given in English. 5. Each answer is worth the indicated score, or part of it, if it is partially correct. 6. If the exercise requires mathematical passages, the points are awarded only if all passages are shown, inside the spaces provided. 7. The solution of the exam will be published on BeeP. You can view your results following the publication on Beep, according to specific instruction that you will receive. 8. The proposed grade will be published on the Politecnico “servizi on line” portal. Any student wishing to reject the grade should do it through the portal, within the publication period. After this deadline, the grade will be automatically consolidated and verbalised. --------------------------------------------------------------------------------------------------------------- MSC therapy for osteoarthritis A new therapy for osteoarthritis requires that mesenchymal stem cells are isolated from the bone marrow and expanded in monolayer. The cell monolayer grows on the bottom of a culture plate in static culture by using a cell medium enriched with grow factors that promote MSC differentiation into collagen-producing cells. After few days in culture the cells are detached, and repeatedly injected in the joint space of the patient to be treated. This therapy has been successfully tested on 100…