Cardias Patches

Pagina 1

1 Cardiac patches and bioartificial heart In the United States, heart donor availability has increasingly failed to keep pace with rising demand. According to the United Network for Organ Sharing, 512 patients on the waiting list died in 1988; 527, in 1989; 650, in 1990, more than 800 in 1991. The number and proportion of potential recipients who die awaiting heart transplantation is increasing every year. Congestive heart failure and arrhythmia are the major causes of death. [1] Bioartificial heart and cardiac patches seem to be the most promising alternatives to the heart transplant and to the heart devices (asVADs, that are devices, only used as a bridge to the transplant). Haneef et al. [2] seeded a 3D collagen scaffold with bone marrow MSCs and thenand stimulated them using electrical stimulation to obtain the differentiation into cardiomyocytes, with the final goal to obtain a functional cardiac patch. With this exercise, we want to characterize and analyze if this device could be a good candidate as a cardiac patch. A cardiac patch is a cellularised thin scaffold that is a promising therapeutic mode for ventricular wall reconstruction. Bibliography [1] McManus RP, O'Hair DP et al. Patients who die awaiting heart transplantation. J Heart Lung Transplant. 1993 Mar-Apr;12(2):159-71. [2] Haneef K., Lila N., et al. Development of bioartificial myocardium by electrostimulation of 3D collagen scaffolds seeded with stem cells. Heart International 7, 70-76 (2012). [4] Mollova M., Bersell K. et al. Cardiomyocyte proliferation contributes to heart growth in young humans. PNAS Early Edition (2012). [5] Redaelli A., Montevecchi F. Biomeccanica. Analisi multiscala di tessuti biologici, Pàtron (2012). [6] Ott H.C., Matthiesen T.S. et al. Perfusion-decellularized matrix: using…