Oral exam questions February 2021

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Domande CTA 1. Designing a clinical study, we need to write a protocol. Think that you are designing a proper trial and explain how would you start thinking about the design. What is PICOS? Practical examples. Which are the possible outcomes of the screening methods? TP,FP,FN,FP. Definitions of the outcome measures of the screening test. Why would you choose a RCT? Why does randomized/blind means? Which is a randomized criteria? Write down the blocked. ICER and CE plane. Which are the parameters that you can sample from a population if we are talking about the monte carlo population? (pt, costs and outcomes) 2. Meta-Analysis, plot/funnel plot. How can we make sure that there is not publication error? We should register the clinical trial in order to explain everything we will do. You declare in advance. When we make decision, we studied 2 possibilities of modelling the decision process, when we adopt one with respect to the other? Can you design a markov model and explain? What is the markov model property? 3. Risk of bias and the countermeasure for them (Robinson-I tool – seminar). CEACF, how to compute it? 4. What is the randomization? Make an example of blocked randomization? Example of stratified randomization? What is markov model, why have we introduced it? What is it the transition matrix? 5. Vaccine production, what are the phases of the approval for a vaccine? Write down the number of people and outcome of the phases. Why the Pyzer vaccine has took only 1 year? Eligibility criteria? How do you select the sample size in a clinical study? Choose a case and explain how to compute the sample size. What is the QALYs? What are the outcome of the sensitivity analysis? Which distribution would we choose for the cost? Monte Carlo simulation? When we have the…