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- Politecnico di Milano
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- Biomedical Engineering
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- Bioengineering of Physiological Control Systems
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Cardiopulmonary Reflexes Sinus Node Frequency Response
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Bioengineering of Physiological Control SystemsBy topic
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BERGERetal. Analysison SINOUSNODE FREQUENCYRESPONSE INVASIVEPROCEDURE: OpenCheststimolation under blockedendogenovsautonomieactivity * AIM: analyzetheSINOUSNODE'sFrequencyResponse wrtbotteVAGALandSYMPATHETICMODULATION Duringthisexperimentsthe2Mechanisms havebeen eudnatedseparately(alternatively),toanalyzethe singleeffectson HR, BUTnormallytheywork togetherinantagonismi *itisasympatheticgangliarithat ma ALTERNATIVESIMULATIONofbotteSystems, cdeectsComedians from3cervico tryingbotteSequentialOrderson differentigroups vertebraandtargetsbotteheartand lungs INPVI: * ELECTRICALSIGNAL: tnainpulses → (VAGUSNERVE) * Firstly, nonbotteCanals@f-toMachEQUILIBRIUMaroundaWP → (STELLATEGANGUON))"^ *ThamSIMULATIONofONECANALwithPULSETRANattimevan.mgimstantaneousFrequencyWHY?Toobtaiua prolungateresponse inFrequencydomain, thatismore OBSCILLATINGFREQUENCYaround → (vagosNerve) explanatoryofthephysidogicala Fixedaveragevalue(f-) normalworkConditions → (STELLATEGANGUON) dosetotherealANSSignals f,#,a Instant. Frequencya psd (ideally)GaussianaWhiteNoisewitha bandLimitedto0.7Hz are-inventare> t 07Hz FÉHZ) MATHEMATICALMODEL (yn(w)= Cross- Spectraldensityoviar.info Su(w)= AutoSpectraldensityINRM ^"&# ✗(f)= SimonsNode (Yul") Sylw)= Autospectraldensityorari "") asympatleetic activationRate GCW)= Sifw) COHERENCE: Kyj(w)= (Yu(w)< itisaMeasureofthepowertransferfromUe) s ya) ifSYSTEMisLINEARandERGODICitestimatesthecansalitybetweenI/0Sulw)Sylw) , gyyiy,; , 1 kt)isFullyprdictablefromult)withtheOPTIMALPREDICTOR ' ① Yct)andult)aren'tcorrelate NB. everythiugabovetheBWe0.7Hzisnbbisle(Noise)thatmustbenottakenintoaccount RESULTS VAGALREGULATION A.Broadbandinput [email protected]→ BROADBANDRESPONSE C.INPUTSPECTRUMandOUTPUTSPECTRUMmo chosetoeachOtter andSAMErangeESTIMATEDGCS)…
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