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- University
- Politecnico di Milano
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- Biomedical Engineering
- Subject
- Bioengineering of Physiological Control Systems
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- Notes · By topic
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Bioengineering of Physiological Control SystemsBy topic
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CHEMOREGULATIONContrasboth • OXIGENATION • CARBON- DIOXIDECONCENTRATION (C)z REGULA]/①N Importanttotakeintoaccount [email protected] Eventwithartificialventilation itis .. . . . ... .µqmguaaqµµepµe⊥÷@STABLE/VITALCONDITIONS Mpeg BREATHING BreathingistheprocessofmouimgairinandouttheLungstoperformthegasexchangebetweenthebodyandthe environmentthatallonstheco, Washout(02- - → Cellularrespiration- - - >Coa- - → washout) •ateachbreathnotthetotaldevantofco, [ALUEOLARGas ②presentiWitkinthebloodiswashedout, so: EXCHANGE yCO2(Vco, Q= Cardiacoutput(Lt/s] BLOODFLOWa Cuco, = VCMOUSCO2concentration Q s (co㱺VR) Caco, ARTERIALBLOODLtofblood )Caco, = arteriaco, concentration }/""" | VENOUSBlood totheheartfromcells adimensionali(HEMORECEPTORSma arethePhysiologieSENSORabletoSENSEandREACTtoCoaconcentration inblood, mainbybyMearnsofpH: ACIDITYis am iimdetectMeasure ofCO2concentration " HowmultiCO2iswashedoutdependson theTIDALVOLUME(themoreairisexhaledthemoreco, canbewashedout) TIDALVOLUME= volumeofairmovedIiroor outOFthelungduringanormalbreath(=0.5L inNORMALSUBJECTS)v PERIODICBREATHING TheCycleChangesoftidalvolume(Vt) !theFocusistheexchamgedvolumeOVERSEVERALBREATHS overseveralbreaths(Breathingperiod: TB) nottheutwaueform theAVERAGEFLOWofVOLUMEintheAIRWAYS: ALMOSTCONSTANT@NORMALCONDITIONSÙe= V' T, ["""1sec] > (consideri.mgafixedBreathingpattern) % 9 ' T, " >EQUILIBRIUM+ Smauchamgesin theDOTsigniStaysforAVGMagnitudenot fortheDERNATNE RESPONSEtoNORMALDISTURBANCE(ACTIVITYandMETABOUCDEMANDS) al VARIABLEdueto ITOSCILLATIONSofPERIOD/CBREATHING PATHOLOGICALABNORMALConditions" Conditions . . . . . IfthephysidogicalregulatingSystembecomesinstable '→ TB HEARTFAILUREor mainpossiblecauses > ""&"" ""&&" s SIGNIFICANTDISTURBANCE(suchas sweepDISORDERSor )> Higertransportationdelays>…
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